Preventing Preterm Birth Initiative, Call for Proposals

Deadline: 15 January, 2013
Open to: non-profit organizations, for-profit companies or other recognized institutions that can successfully execute the activities in their respective topic areas
Grants: $1,300,000 USD for the entire three year funding period


The Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) is now accepting letters of inquiry to identify and develop research sites in low- and middle-income countries as part of a collaborative, multicenter research initiative to investigate causes of and novel strategies for prevention of preterm birth and stillbirth through prospective studies of pregnant women.

This Request for Proposals (RFP) is the second phase of the Preventing Preterm Birth initiative, part of the Bill & Melinda Gates Foundation’s Grand Challenges in Global Health. The objective of this RFP is to identify global health research sites to serve as part of a research network to conduct well-characterized, standardized, prospective studies of pregnant women, conducted in partnership with investigators already funded by the PPB initiative. It is intended that these multi-center investigations will examine the multiple and complex causes of preterm birth in an effort to identify innovative strategies for preterm prevention in low- and middle-income countries.


Applicant organizations must be non-profit organizations, for-profit companies or other recognized institutions that can successfully execute the activities in their respective topic areas. Grantees awarded projects will be required to actively collaborate with members of relevant research consortiums. Applications from the developing world are encouraged.

Successful proposals should include documentation of the research site’s demonstrated capacity to conduct prospective studies of pregnant women and investigate birth outcomes. The site must have the capacity to enroll women early in pregnancy, preferably in the first trimester or soon thereafter, and implement systems for accurate determination of gestational age using ultrasound and/or other precise methods for determination of gestational age. In addition, the site must demonstrate capacity to follow women during pregnancy; assess medical and other complications of pregnancy; collect blood, urine, and vaginal swabs during pregnancy; and characterize specific birth outcomes, including stillbirth and specific preterm phenotypes (e.g. preterm premature rupture of membranes, small for gestational age, medically-indicated preterm birth, and spontaneous preterm birth).


GAPPS anticipates each grant will not exceed $1,300,000 USD for the entire three year funding period. Indirect costs are included in the total award.

How to apply?

Step 1:
Download the application and instructions from the official website
Step 2:
Submission of a Letter of Inquiry (LOI) to GAPPS by January 15, 2013. LOIs should be 3-4 pages in length
(four page limit), which includes a general questions face page.
Applicant organizations submitting an LOI must fully meet the eligibility criteria listed in this RFP.
Elements included in the LOI must include:

  1. Project background and rationale
  2. Project objectives
  3. General approach
  4. Anticipated outcomes should include: number of women enrolled, gestational age at enrollment, accurate gestational age determination, follow-up rates, ability to characterize medical complications of pregnancy and preterm birth phenotypes, and anticipated number and proportion of deliveries for which data and specimens could be collected.
  5. Investigator and organizational capacity
  6. Environment and resources
  7. Estimated budget

The deadline to submit letter of inquiry is 15 January 2013.

Please submit your initiative-related questions to [email protected]

For more details see the FAQs

The Official Website

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